mRNA scientist /associate, uBriGene Biosciences, Germantown, MD
uBriGene Biosciences -
Germantown, MD,
US
mRNA scientist /associate
Date Posted: 2024-06-15
Job description
Summary:
We are looking for an experienced Scientist whose work will focus on mRNA products development at our Process Development Department. The incumbent is expected to possess a comprehensive, hands-on background in aspects of molecular biology including in vitro transcription and DNA/RNA biochemical and structural analysis. Experience with LNP encapsulation and analysis is highly desired.
RESPONSIBILITIES:
We are looking for an experienced Scientist whose work will focus on mRNA products development at our Process Development Department. The incumbent is expected to possess a comprehensive, hands-on background in aspects of molecular biology including in vitro transcription and DNA/RNA biochemical and structural analysis. Experience with LNP encapsulation and analysis is highly desired.
RESPONSIBILITIES:
- Design and perform Biochemical and Molecular Biological experiments like DNA/RNA extraction, PCR/qPCR, in vitro transcription, and LNP encapsulation.
- Perform DNA/RNA analysis and report results.
- Develop product specifications and SOPs.
- Be able to perform routine bench work under limited supervision, prioritize responsibilities effectively, and complete assignments on time.
- Be able to analyze, interpret, and present results to project teams, and write technical reports.
- Assist the development of robust and scalable downstream processes like liquid chromatography (FPLC) and diafiltration/concentration (TFF).
- Support the scale-up of upstream/downstream processes and technology transfer to the cGMP manufacturing and quality control (QC) groups for clinical material production/analysis.
- Maintain domain expertise in new technologies and scientific literature.
- QUALIFICATIONS:
- B.S. with 3+ years, M.S. with 1+ years of relevant experience in industry, or PhD in Biochemistry/Chemistry/Chemical Engineering/Molecular Biology or related scientific subject areas with 0-2 years of proven experience.
- Sound knowledge of varied aspects of molecular biology, RNA biochemistry and LNP encapsulation.
- Experience with aspects of process development such as scale up, upstream and downstream processes.
- Experiences with common analytical techniques such as gel/capillary gel electrophoresis, fragment analyzer, pH and osmolarity assays.
- Ability to design, organize and execute complex experiments
- Ability to work independently while being a team player
- Able to prepare and make comprehensive presentations